Scientists are discovering an unexpected connection between intestinal and heart health

One of the most buzz (and the most controversial) the ketogenic diet.

Embraced by many, keto revolves around a way of eating high in fat, low in carbohydrates and with proper protein. However, many scientists are skeptical of the diet, discussing its drawbacks it can outweigh its benefits.

A to study published Friday in the magazine Science reinforces the main argument against keto: a high-fat diet can cause long-term health problems.

The study team examined the link between a high-fat diet and heart disease, finding that intestinal bacteria can influence this relationship. We can control these intermediate factors by moderating the amount of fat in our diet.

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Why is it a trick? When you eat a high-fat diet, a few things happen:

First, diet increases intestinal inflammation, damaging intestinal cells. At the same time, diet can affect the mitochondria of intestinal cells (the power of the cell), causing these cells to produce more oxygen and nitrates.

Oxygen and nitrate stimulate two things: the proliferation of harmful bacteria such as E. coli and the production of the metabolite TMA (trimethylamine). The liver then converts TMA to TMAO (trimethylamine-N-oxide). TMAO can increase the relative risk of mortality, especially when it comes to heart disease.

Inflamed and weakened intestines allow the possibility of TMAO to travel to the heart, where it settles in the arteries as a plaque that restricts blood flow.

Critically, you can avoid this process (inflammation, harmful bacteria, excess TMAO) by eating a balanced diet.

The praised keto diet, for example, has been shown to pose a risk of heart disease. Red meat can be an important part of keto and red meat is high hill – A nutrient that becomes TMA (and then TMAO).

Science in action – The study team examined three different but interconnected factors in mice:

  • Changes in the intestinal lining
  • Mitochondrial dysfunction
  • Effects of high-fat diets on E. growth. Coli

The researchers began raising mice on a high-fat diet. They then introduced E. coli into the systems of mice in an effort to make their entrails resemble the human gut.

Subsequently, the high-fat diet caused intestinal inflammation and damaged intestinal cells. The E. Cole from mice bloomed due to extra oxygen and nitrate.

These three factors – intestinal inflammation, dysfunctional mitochondria and harmful bacteria – conspire to increase the risk of heart disease.

How does this affect longevity: You’ve probably heard that high-fat diets aren’t the best, but this study provides a new reason why.

It has been established that a high fat diet can cause obesity, which in turn can lead to a lot of health conditions, which vary of diabetes a an increased risk of heart attack. This study allows us to understand how fat affects individual cells and how they work.

Previously, this study team found that the relationship between cells lining the gut and intestinal microbes allows for a healthy microbiome. It is now understood that a high-fat diet can alter this relationship by promoting the growth of “bad” microbes.

A study of mice included in this research revealed that a drug called 5-aminosalicylic acid, which is typically used to treat intestinal diseases, could prevent the negative reaction caused by diet.

Although the study team hopes to be able to use this information to develop a similar therapeutic treatment for humans, for now, the best solution is based on what we decide to eat.

Hack score out of 10 – πŸ–πŸ–πŸ–πŸ–πŸ–πŸ– (6/10)

https://www.inverse.com/science/fat-heart-disease

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